Children:
- Henry Isenberg was born before 1790; died about 1809 in Boone's Creek, , Washington County, Tennessee.
- Jacob Isenberg was born about 1790 in Frederick County, , , Maryland; died about 1860 in Hawkins County, , , Tennessee.
- 1. Mary Isenberg was born before 1790.
- Daniel Isenberg was born about 1799 in , Brunswick County, Virginia Colony, ; died about 1868 in Monroe County, , , Kentucky.
- John Isenberg was born about 1801 in Frederick County, , , Maryland; died about 1830 in Kentucky, , , .
- Margaret Isenberg was born about 1805.
- Elizabeth Isenberg was born about 1808.
- Nicholas Alexander Jr. Isenberg was born on 12 Dec 1809 in Washintgon County, , , Tennessee; died on 18 Jun 1862 in Washintgon County, , , Tennessee; was buried in Isenburg Cemetery, , Washington County, Tennessee.
- Sarah Isenberg was born about 1810; died about 1880 in Washintgon County, , , Tennessee.
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Bef 1790 - 